Background and Purpose: Academic burnout is one of the important indicators of mental health among educated people and has negative effects on the psychological well-being of students and their families. The purpose of this study was explaining students' academic burnout based on self-compassion and sense of coherence.
Method: The research method was descriptive and correlational. The sample consisted of 373 students in Ardebil city in the academic year of 2016-2017 who were selected by multi-stage cluster sampling. Academic burnout scale (Berso et al, 1997), sense of coherence questionnaire (Antonovsky, 1987) and self- compassion scale (Neff, 2003) were used as a research tools. Data were analyzed using Pearson correlation test and multiple regression analysis.                                          
Results: The effect of comprehensibility (β = -0.067: p <0.003), self- kindness (β = -0.167: p <0.012), mindfulness (β = -0.317: p <0.001) on academic burnout is positive and significant and effect of isolation (β = 0.745: p <0.001) on academic burnout is negative and significant. In addition, self-compassion and sense of coherence predicted 89% and 86% of variance of academic burnout scores of students (p<0.001).    
Conclusion: Based on the results of this study, self-compassion and sense of coherence by providing effective coping strategies in the face of academic stress and creating academic motivation affect students' academic achievement and reduce their academic burnout.