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:: Volume 10, Issue 1 (Vol10 No1 Spring 2023- 2023) ::
J Child Ment Health 2023, 10(1): 125-142 Back to browse issues page
The Effectiveness of Pharmacotherapy on Executive Functions and Externalizing Behavior Problems in Children with Attention Deficit-Hyperactivity Disorder: A Follow-up Study
Fatemeh Hedayati Shalkouhi1 , Bahman Akbari * 1, Elham Bidabadi2 , Leila Moghtader1
1- Department of Psychology, Rasht Branch, Islamic Azad University, Rasht, Iran
2- Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (706 Views)
Background and Purpose: Attention Deficit/Hyperactivity Disorder (ADHD) is a chronic neuro-psychological disorder characterized by a consistent pattern of attention deficit, impulsivity, and hyperactivity. This condition significantly impairs the executive functions of individuals affected by it and serves as a contributing factor to their behavioral difficulties. Therefore, the purpose of this study was to determine the effectiveness of Pharmacotherapy on executive functions and externalizing behavior problems in children with ADHD: A follow-up study.
Method: The present study employed a quasi-experimental design with a pretest-posttest structure, incorporating a control group. The statistical population included all male children with ADHD who were attending exceptional schools of Rasht city in the second semester of the academic year 2020-2021. The research sample consisted of 24 children from the specified community, who were selected using a convenience sampling technique and randomly assigned to two groups (12 in the pharmacotherapy group and 12 in the control group). These children were then randomly divided into two groups, with 12 participants in the pharmacotherapy group and 12 participants in the control group. The data collection instruments utilized in this study consisted of the Behaviour Rating Inventory of Executive Function (BRIEF) developed by Gioia et al. (2000) and the Child Behavior Checklist (Achenbach's, 2001). The data were subjected to analysis of covariance and dependent t-test using SPSS22.
Results: The findings of the study indicate that the implementation of pharmacological interventions had a significant positive impact on enhancing overall executive functions, as well as reducing externalizing behavior issues and their associated components in children diagnosed with ADHD (p<0.001). Furthermore, the findings of the study indicate that there was no statistically significant disparity between the mean scores of the experimental group in the post-test and follow-up phases, specifically in relation to general executive functions, externalizing behavior problems, and their respective components. This suggests that the effectiveness of pharmacotherapy remained consistent over a period of 2 months (p>0.05).
Conclusions: Pharmacotherapy with effect on brain structures such as right inferior frontal cortex and insula as well as dopamine and norepinephrine neurotransmitters leading to the strengthening of self-regulation skills, improves brain functio. Finally, it will improve executive functions and reduce Internalizing Behavior Problems in children with ADHD.
Article number: 9
Keywords: Pharmacotherapy, executive functions, externalizing behavior problems, attention deficit-hyperactivity disorder
Full-Text [PDF 1728 kb]   (161 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2022/04/28 | Accepted: 2022/08/3 | Published: 2023/06/21
References
1. Saputro D. Is Neurofeedback therapy beneficial for Attention Deficit Hyperactivity Disorder? Scientia Psychiatrica. 2021; 2(1): 46-50. [Link] [DOI:10.37275/scipsy.v2i1.29]
2. Barkley RA. Taking charge of ADHD: The complete, authoritative guide for parents. New York: Guilford press; 2020, pp 88-89. [Link]
3. Dalrymple RA, Maxwell LM, Russell S, Duthie J. (2020). NICE guideline review: Attention deficit hyperactivity disorder: diagnosis and management (NG87). Arch Dis Child Educa Pract Ed. 2020; 105(5): 289-293. https://doi: 10.1136/ archidischild-2019-316928. [Link] 10.1136/archdischild-2019-316928 []
4. Sayal K, Prasad V, Daley D, Ford T, Coghill D. ADHD in children and young people: prevalence, care pathways, and service provision. Lancet Psychiatry. 2018; 5(2): 175-186. [Link] [DOI:10.1016/S2215-0366(17)30167-0]
5. Cortese S. Pharmacologic treatment of attention deficit-hyperactivity disorder. New England Journal of Medicine. 2020; 383(11): 1050-1056. https://doi: 10.1016/S2215-0366(17)30167-0. [Link] [DOI:10.1016/S2215-0366(17)30167-0]
6. Mechler K, Banaschewski T, Hohmann S, Häge A. Evidence-based pharmacological treatment options for ADHD in children and adolescents. Pharmacology and Therapeutics. 2021; 230:107940. (In Press). https://doi.org/10.1016/j.pharmthera.2021.107940 [DOI:10.1016/j.pharmthera.107940. [Link]]
7. Gordon CT, Hinshaw SP. Executive functions in girls with and without childhood ADHD followed through emerging adulthood: Developmental trajectories. J Clin Child Adolesc Psychol. 2019: 49(4): 509-523. http://dx.doi: 10.1080/15374416.2019.1602840. [Link] [DOI:10.1080/15374416.2019.1602840]
8. Soto EF, Irwin LN, Chan ES, Spiegel JA, Kofler MJ. Executive functions and writing skills in children with and without ADHD. Neuropsychology. 2021; Advance online publication. https://doi.org/10.1037/neu0000769 [DOI:10.1037/neu0000769. [Link]]
9. Huhdanpää H, Klenberg L, Westerinen H, Bergman PH, Aronen ET. Impairments of executive function in young children referred to child psychiatric outpatient clinic. Clinical child psychology and psychiatry. 2019, 24(1): 95-111. https://doi:10.1177/1359104518786537. [Link] [DOI:10.1177/1359104518786537]
10. Sosic-Vasic Z, Kröner J, Schneider S, Vasic N, Spitzer M, Streb J. The association between parenting behavior and executive functioning in children and young adolescents. Front Psychol. 2017; 8: 472-479. https://doi.org/10.3389/fpsyg.2017.00472 [DOI:10.3389/ fpsyg.2017.00472. [Link]]
11. Yousefi R, Soleimani M, Ghazanfariyanpoor S. Comparison between switching and creativity among bilingual and monolingual children. Jrehab. 2017; 18(1):1- 12. https://doi: 10.21859/jrehab-18011. (Persian). [Link] [DOI:10.21859/jrehab-18011]
12. Serpell ZN, Esposito AG. (2016). Development of executive functions: Implications for educational policy and practice. Policy Insights Behav Brain Sci. 2016, 3(2): 203-210. DOI: 10.1177/2372732216654718. [Link] [DOI:10.1177/2372732216654718]
13. Kaga Y, Ueda R, Tanaka M, Kita Y, Suzuki, K, Okumura Y., Inagaki M, et al. Executive dysfunction in medication-naïve children with ADHD: A multi-modal fNIRS and EEG study. Brain and Development. 2020; 42(8): 555-563. https://doi: 10.1016/j.braindev.2020.05.007. [Link] [DOI:10.1016/j.braindev.2020.05.007]
14. Ahmad SI, Hinshaw SP. Attention-deficit/hyperactivity disorder, trait impulsivity, and externalizing behavior in a longitudinal sample. J Abnorm Child Psychol. 2017; 45(6): 1077-1089. https:/doi: 10.1007/s10802-016-0226-9. [Link] [DOI:10.1007/s10802-016-0226-9]
15. Mirnasab M. Comorbidity of attention deficit hyperactivity. Studies in Medical sciences. 2011; 22(1): 53- 61. (Persian). [Link]
16. Mulraney M, Zendarski N, Mensah F, Hiscock H, Sciberras E. Do early internalizing and externalizing problems predict later irritability in adolescents with attention-deficit/hyperactivity disorder? Aust N Z J Psychiatry. 2017; 51(4): 393-402. https://doi: 10.1177/0004867416659365. [Link] [DOI:10.1177/0004867416659365]
17. Yeganeh T, Hossein Khanzadeh A, Zarbakhsh M. The Effectiveness of Cognitive-Behavioral Social Skills Training (CBSST) on Reducing Symptoms of Students with Externalizing Behavior Disorders. Psychology of Exceptional Individuals. 2013; 3(11): 41- 63. (Persian). [Link]
18. Liu X, Xiao H, Xie F, Zheng X, Du Y, Huang Y, Lin H. Current pharmacotherapy for preschool children with attention deficit hyperactivity disorder. J Pharm Biomed Sci. 2018; 8(2), 14-21. [Link]
19. Sibley MH, Graziano PA, Coxe S, Bickman L, Martin P. (2021). Effectiveness of motivational interviewing− enhanced behavior therapy for adolescents with attention-deficit/hyperactivity disorder: A randomized community-based trial. J Am Acad Child Adolesc Psychiatry. 2021; 60(6): 745-756. https://doi: 10.1016/j.jaac.2020.07.907. [Link] [DOI:10.1016/j.jaac.2020.07.907]
20. Oliva F, Malandrone F, di Girolamo G, Mirabella S, Colombi N, Carletto S, Ostacoli L. (2021). The efficacy of mindfulness-based interventions in attention-deficit/hyperactivity disorder beyond core symptoms: A systematic review, meta-analysis, and meta-regression. J Affect Disord. 2021 [DOI:10.1016/j.jad.2021.05.068]
21. 292: 475-486. https://10.1016/j.jad. 2021.05.068 [Link] [DOI:10.1088/1475-7516/2021/05/068]
22. Azam F, Saberi H, Kazemi Kavaki A. The Effectiveness of Neurofeedback and " Transcranial Direct Current Stimulation" on the Executive Function of Response Inhibition of Boys 6 to 11 years with Attention Deficit- Hyperactivity Disorder. JHPM. 2020; 9 (3):49-60. (Persian). [Link]
23. Kermani A, Basharpoor S, Narimani M. The Effectiveness of Computerized Visual-Motor Skills Training on the Severity of Symptoms of Children with Attention Deficit / Hyperactivity Disorder. J Child Ment Health. 2022; 9 (3):1-14. https://doi:10.52547/jcmh.9.3.2. [Link] [DOI:10.52547/jcmh.9.3.2]
24. Delazar E, Hadianfard H, Aflakseir A, Kousha M. The Effectiveness of Mindfulness and Modification Therapy on Impulsivity and Risk-Taking Behaviors in Adolescents with Attention Deficit-Hyperactivity Disorder. J Child Ment Health. 2022; 9 (1): 100-118. https://doi:10.52547/jcmh.9 .1.8 [DOI:10.52547/jcmh.9.1.8]
25. Karaosman T, Gumus YY. (2022). The effects of methylphenidate treatment on bullying perpetration and victimization in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc psychopharmacology. 202232(2), 107-116. https://doi: 10.1089/cap.2021.0119. [Link] [DOI:10.1089/cap.2021.0119]
26. Young JR, Yanagihara A, Dew R, Kollins SH. Pharmacotherapy for Preschool Children with Attention Deficit Hyperactivity Disorder (ADHD): Current Status and Future Directions. CNS drugs.2021; 35: 403-424. doi: 10.1007/s40263-021-00806-z. [Link] [DOI:10.1007/s40263-021-00806-z]
27. Grandjean A, Suarez I, Miquee A, Da Fonseca D, Casini L. Differential response to pharmacological intervention in ADHD furthers our understanding of the mechanisms of interference control. Cogn Neuropsychol. 2021; 1-15. https://doi.org/10.1080/02643294.2021.1908979 [DOI:10.1080/02643294.2021.1908979. [Link]]
28. Sharma A, Couture J. A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Annals of Pharmacotherapy. 2014; 48(2): 209-225. [DOI:10.1177/1060028013510699]
29. Faraone SV. The pharmacology of amphetamine and methylphenidate: relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev. 2018; 87: 255-270. [DOI:10.1016/j.neubiorev.2018.02.001]
30. Torkman M, kakabraee K, Hosseini S. 'The effectiveness of drug therapy on executive functions, behavioral problems and clinical symptoms of attention deficit / hyperactivity disorder', medical journal of Mashhad university of medical sciences. 2021; 64(1): 24- 32. [Persian]. https:// 10.22038/MJMS.2021.18071. [Link]
31. Azami S, Talepasand S, Nazifi M, Issac Rahimian. Compare the Effectiveness of Rehabilitation and Drug Therapy Approaches in Improving Clinical Symptoms and Academic Performance of Children with Attention Deficit/ Hyperactivity Disorder. Middle Eastern Journal of Disability Studies. 2017; 7(13): 1-8. (Persian). DOR:20.1001.1.23222840.1396.7.0.88.6. [Link]
32. Hedayati Shalkouhi F, Akbari B, Bidabadi E, Moghtader L. Comparison of the Effectiveness of Pharmacotherapy and Neurofeedback on Improving Executive Functions in Children with Attention Deficit-Hyperactivity Disorder. J Child Ment Health. 2022; 9 (1): 192-208. https://doi: 10.52547/jcmh.9.1.13 [Link] [DOI:10.52547/jcmh.9.1.13]
33. Hakimjavadi M, Gholamali Lavasani M, Shakouri HR, Abdolahifar A, Momeni F. Comparison of the efficacy of behavioral, medicinal therapy on reduction of hyperactivity/ attention deficit disorder symptoms in children. J Gorgan Univ Med Sci. 2015; 17(1): 42- 47. (Persian). [Link]
34. Azimi A, Makund Hosseini S, Azimi R, Hasanpour M. The effectiveness of Ritalin on the executive functioning of children with attention deficit/hyperactivity disorder in Bander Gestalt tests and Raven-Rangi matrices, the second international conference on modern research in Management, Economics and Human Sciences;2014. https://civilica.com/doc/493837. (Persian). [Link]
35. Mei H, Xie R, Li T, Chen Z, Liu Y, Sun C. Effect of Atomoxetine on Behavioral Difficulties and Growth Development of Primary School Children with Attention-Deficit/Hyperactivity Disorder: A Prospective Study. Children. 2022; 9(2): 212-223. https://doi: 10.3390/children9020212. [Link] [DOI:10.3390/children9020212]
36. Van Stralen JP. A controlled trial of extended-release guanfacine and psychostimulants on executive function and ADHD. J Atten Disord. 2020; 24(2): 318-325. https://doi: 10.1177/1087054717751197. [Link] [DOI:10.1177/1087054717751197]
37. Gioia GA, Isquith PK, Guy SC, Kenworthy L. Behavior rating inventory of executive function. Child Neuropsychol. 2000, pp: 45-100. [Link] [DOI:10.1037/t73087-000]
38. Nodei K, Sarami G, Keramati H. The relation between function and working memory capacity and Students' reading performance: The role of age, sex and intelligence. Journal of Cognitive Psychology. 2016; 4(3): 11-20. [Persian]. [Link]
39. Achenbach TM, Rescolar LA. Manual for the ASEBA School - age forms and profiles. Burlington: ASEBA. 2001. [Link]
40. Minaee A. Adaptation and standardization of child behavior checklist, youth self-report, and teacher's report forms. JOEC. 2006; 6(1): 529- 558. (Persian). https://doi:20.1001.1.16826612.1385.6.1.3.6. [Link]
41. Yazdkhasti F, Oreyzi H. Standardization of Child, Parent and Teacher's Forms of child behavior checklist in the city of Isfahan. LJPCP. 2011; 17(1):60 -70. (Percian). [Link]
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Hedayati Shalkouhi F, Akbari B, Bidabadi E, Moghtader L. The Effectiveness of Pharmacotherapy on Executive Functions and Externalizing Behavior Problems in Children with Attention Deficit-Hyperactivity Disorder: A Follow-up Study. J Child Ment Health 2023; 10 (1) : 9
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Volume 10, Issue 1 (Vol10 No1 Spring 2023- 2023) Back to browse issues page
فصلنامه سلامت روان کودک Quarterly Journal of Child Mental Health
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